O-11 Patient-reported outcome measures, one-year after COVID-19: A Cohort Study in South Trinidad, 2020– 2021.

Methods: In this retrospective cohort study a sample of 324 participants, >/= 18 years, who were symptomatic with laboratory confirmed COVID-19 infection between March 2020 and May 2021, were followed up after 12-months for persistent symptoms. Multivariable adjusted linear and logistic regression models estimated the ORs, ß coefficients and 95% CIs for associations between disease severity and long-term health consequences.

Results: A total of 324/431 eligible participants were enrolled, response rate 75.2%, after 107 were excluded. The median (IQR) age was 41.0 (34-52) years, with 51.23% men and 33.02% with co-morbidities. One year later, 60% reported ≥ 1 persistent symptom: dyspnoea (52.16%), fatigue (42.59%), muscle weakness (31.48%); Patient Health Questionnaire 4 (PHQ-4): anxiety/depression (13.58%). Overall, in the unadjusted analysis, participants with moderate/severe illness, had a significantly increased risk of developing fatigue or muscle weakness (p=0.043); anxiety/depression (p<0.001); breathlessness (p<0.001) and reduced Health-Related Quality of Life (HRQoL (p<0.001). When adjusted for age, gender and co-morbidities, their risk of developing fatigue or muscle weakness, anxiety/depression, breathlessness was nullified, except for HRQoL. Overall, the mean standard deviation (SD) health index value score was 0.931 (0.13), comparable to the national norms of 0.95; for those with moderate/severe illness, mean (SD), 0.894 (0.16), with a statistically significant decrease compared to mild illness (p<0.001).

Conclusion: One-year post-acute COVID-19 infection, a significant proportion of survivors have persistent symptoms. The health index value for those with moderate/ severe illness was below the population norms. Interventions should be prioritized for their long-term recovery.