O-24 Assessing Microvascular Complications in Diabetic Foot using Novel Diagnostic Equipment
Author(s):
A Greenidge , KR Quimby , I Hambleton , R Landis
Type Of Study:
- Experimental or Intervention Study
Year of Presentation:
2022
Objective: To investigate assessment of endothelial dysfunction, tissue oxygenation and neuropathy by non-invasive devices in diabetes and diabetic foot.
Methods: The Wound Healing Study is a case control study in adults with type II diabetes, recruited from healthcare facilities. Fifty cases (diabetic foot) and controls (no diabetic foot) were matched for age, sex and diabetes duration. Vascular assessments including endothelial function and arterial stiffness were measured using EndoPAT 2000 and oxygenation was assessed by the RM200 SO2 monitor. Vibration Perception Threshold readings were also taken using the Neurothesiometer. Odds ratios were determined using logistic regression; unadjusted and adjusted for age, sex and diabetes duration.
Results: 17.8% of cases and 36.7% of controls were categorised with impaired endothelial function (OR 2.85, 95% CI 1.04–7.76). There was no difference in the measurement of arterial stiffness between the two groups. 37.2% of cases vs 30.8% of controls were classified as having hypoxic limbs (OR 1.17, 95% CI 0.45–3.01). 18.6% of case measurements were hypoxic compared to 15.4% in the controls (OR 1.00, 95% CI 0.98–1.03). 52.0% of cases and 18.4% of controls exhibited loss of the protective sensation in the feet (adjusted OR 5.42, 95% CI 2.07–14.21, p = 0.01).
Conclusion: Endothelial dysfunction detected by EndoPAT, and tissue SO2 detected by RM SO2 do not have as great an input on microvascular damage in diabetic foot, as nerve damage, detected by Neurothesiometer.