O-25 Risk factors associated with change in transcranial doppler velocities in sickle cell disease: a Jamaican study
Author(s):
C Bryan , JP Louboutin , M Reid
Year of Presentation:
2022
Objective: To determine the association between the
anthropometry and haematological variables with variation in Transcranial Doppler (TCD) velocities one year after
baseline measurements (study period).
Methods: Eligible patients aged 2–16 years registered at the Sickle Cell Unit, University of the West Indies, Mona and who received a minimum of 2 TCD measurements 12 months apart for the period April 2012 to December 2020 were recruited. Mixed model regression analyses were performed to assess the relationship between variation in TAMV, haematology, anthropometry adjusting for Hydroxyurea usage. The study was approved by Mona Campus Research Ethics Committee.
Results: Forty-eight patients were included in the study (20 males, 28 females) with a mean (+/– SD) age of 6.7 (+/– 2.4) years and 7.4 (+/– 2.6) years at baseline and 1 year post respectively. There were no significant differences in haemotogical variables and TAMV by study period. Adjusting for Hydroxyurea use, increasing reticulocyte count was associated with higher TAMV (p < 0.031). In contrast higher weight (p < 0.021), haemoglobin concentration (p < 0.001) and red cell counts (p < 0.025) were associated with lower TAMV.
Conclusion: The findings suggest that anaemia, marrow activity and nutritional status could be targets for interventions to modulate TCD velocities.