O-53 The Biochemical Profile of Patients with Localized Prostate Cancer

Methods: This prospective study, investigates 41 histologically confirmed PCa patients diagnosed at the University Hospital of the West Indies between January 2023 and August 2024. Each participant provided approximately 10 mL of blood to assay total prostate specific antigen (tPSA) and other special and routine tests. All data were analyzed using the Statistical Package for Social Science version 22.0 and, differences with p < 0.05 were deemed statistically significant.

Results: The largest proportion (36.6%) of the participants were in the 60-69 years age group and the mean age was 66.4 years. The tPSA was significantly elevated with a mean of 38.5 ng/mL and 93.9% had tPSA above 4.0 ng/mL. The liver function tests profile showed that serum aspartate aminotransferase (AST) levels were elevated in 19.4% and serum alanine aminotransferase (ALT) in 22.2% of participants. Sixty two and a half percent (62.5%) of participants showed increased levels of serum amylase and 31.3% showed abnormally high creatine kinase (CPK) levels. Analysis of the data using One-Sample t-test showed that there are significant differences between elevated and normal levels for AST (p = 0.003), amylase (p < 0.001) and CPK (p < 0.001). Anemia screening showed 24.2% of the participants had elevated serum ferritin levels, 16.1% had elevated transferrin saturation (TS) and 25.0% had decreased total iron binding capacity (TIBC). There were statistically significant differences between higher and normal levels for ferritin (p = 0.002) and TIBC (p = 0.009).

Conclusion: The results of this study demonstrated that biomarker enzymes including AST, ALT, CPK and amylase, as well as ferritin are elevated in men with localized PCa. The findings could be useful in developing diagnostic and prognostic models tailored to Jamaican men with this disease.