O-57 Compliance with Surviving Sepsis Campaign One Hour Bundle and Sepsis Related Twenty-Eight Day Mortality at the University Hospital of the West Indies.
Author(s):
A Henry, S French
Year of Presentation:
2025
Objective: To evaluate sepsis management at the University Hospital of the West Indies (UHWI) using the Surviving Sepsis Campaign (SSC) one hour bundle. Compliance
with the SSC one hour bundle is comparable to other institutions and there is no difference in 28-day mortality between
patients who have all the components initiated and those
who did not.
Methods: This was a monocentric, prospective clinical trial carried out in the emergency department at UHWI from May 1 to November 30, 2022. The study was carried out in two phases. Phase one spanned from May 1 to July 31, 2022, and phase two from August 1 to November 30, 2022. Phase one involved research assistants training, and documentation of usual care. In phase two, staff received detailed information about the sepsis one-hour bundle and the process of identification, enrollment and documentation repeated.
Results: The total sample was 124 of whom 59.86% were females. Sixty participants were enrolled in phase one, 53% of them died within 28 days. Also, 60% of the participants received antibiotics and 80% received intravenous fluid (IVF) within an hour. Of those who received antibiotics, 64% died. Of those who received IVF, 58.% died. In phase two, 41.% of the participants died within 28 days. Also, 56% of the participants received antibiotics and 76.% received IVF within an hour. Of those who received antibiotics, 36.% died. Of those who received IVF, 54.% died. Chi-square showed that there was no relationship between gender and mortality (p = .56). Chi-square and binary log regression also showed no statistical significance between phase and mortality (p = .18). Levene’s Test and T test showed that mortality was not affected by the number of SSC components completed in either phase (F = 0.02, p = .88), (t(121) = -0.54, p = .59, 95% CI [-0.41, 0.23]) Chi-square testing showed mortality was also not affected by the number of SSC components performed (X2(1) = 2.44, p = .12). Of all the SSC components, only IVF administration was associated with higher 28-day mortality (odds ratio = 0.17, 95% CI [0.05, 0.61], p = .01).
Conclusion: Compliance with antibiotic and intravenous fluid administration within an hour were similar for both phases. Neither compliance rate nor mortality showed significant statistical difference between the phases.