O-75 Prognosis of Nephrotic Syndrome in children at Georgetown Public Hospital Corporation.

Methods: An analytical, retrospective cohort study was done at the Georgetown Public Hospital Corporation. The charts of pediatric patients diagnosed with nephrotic syndrome and admitted for treatment over the period of 1st January, 2010 – 1st June 2015 were reviewed. The study population comprised 131 pediatric patients. The demographics and the outcomes of these patients were recorded.

Results: A comparison of the mean age of diagnosis for patients who developed chronic renal failure versus all other outcomes was significant (p = 0.013). A male preponderance was found among the children diagnosed with nephrotic syndrome at Georgetown Public Hospital Corporation. Response to steroid therapy typically ranges from 80-90%. This study shows an overall response to steroid therapy of 67.2%, this together with the demographic associations and findings of a higher mean age (9.6 ± 2.9 years) of diagnosis for children who later develop chronic renal failure indicates that other subtypes of nephrotic syndrome may be the likely cause of disease. These findings indicate determination of subtype by renal biopsy for targeted diagnosis. This study recorded a lower percentage, with 3.8 % of the population developing chronic renal failure as compared to other studies.

Conclusion: In general, mortality attributed to nephrotic syndrome is low. The overall mortality reported in previous studies ranged from 2.2 %- 3.1%. Our study had a single death, giving a prevalence of 0.8%, which reflects the lowering trend of childhood deaths associated with nephrotic syndrome. Nevertheless, the study presents data which supports the use of biopsy to diagnose the type of nephrotic syndrome prior to starting steroid treatment.