P-04 An Evaluation of Lpid Profile and Hematology Profile in Down Syndrome Children & Adolescents in Guyana- a pilot study

Methods: Children and adolescents clinically diagnosed with Down syndrome (DS) between the ages of 4 and 18 years were enrolled for the study based on the inclusion criteria. Mindray automated haematological analyzer and Envoy 500+ automated biochemical analyzer was used. Mean ± Standard Deviation (Mean±SD) was used for rep- resenting the data. A t-test was done to compare the lipid profile values with the defined local reference ranges. 

Results: All participants were included in the study. The Mean±SD values obtained for total cholesterol, triglycerides, and VLDL were included 152.7mg/dL ± 39.3mg/dL, (p=0.2), 78.7mg/dL ± 30.1 mg/dL, (p=0.1), and 15.8mg/dL ± 6.1mg/dL (p=0.002) respectively. The Mean±SD were recorded for White Blood Cell (WBC), haematocrit, Red Blood Cells Count (WBC), Haemoglobin (Hb), haem- atocrit, Red Blood Cell Count (RBC), and platelet count were 5.9 ± 2.4L (p=0.09), 13.0 ± 1.4g/dL, (p=0.06), 41.9 ± 4.2% (p=0.9), 4.6 ± 0.6L (p=0.4), and 266.6 ± 81.8L (p=0.3) respectively. Only mean values of MCHC, MPV and Tri- glycerides values were below the reference values. All participants were included in the study. The Mean ± SD values obtained for total cholesterol, triglycerides, and VLDL were 152.7mg/dL ± 39.3mg/dL (p=0.2), 78.7mg/dL ± 30.1 mg/dL (p=0.1), and 15.8mg/dL ± 6.1 mg/dL (p=0.002) respectively. Minimum and maximum total cholestrol, triglycerides and VLDL were 121-235mg/dL; 37–114mg/dL; 11–23mg/dL respectively.

Conclusion: Although the mean values of VLDL were statisitically significant, the values reported for the total cholestorol and triglycerides do not deviate statistically from the established values. To find conclusive differences, large sample size must be included for testing.