P-65 Amiodarone Induced Hypothyroidism- A Case Study

Methods: This is a case study that reviews several research papers critiquing the pros and cons of Amiodarone use in a clinical setting. Best practice decisions are highlighted in what is done around the world in both first-world settings and rural communities

Results: Even though the cases discussed may be common and easily treatable, especially with new guidelines, research data available, better screening options, and new medication, Amiodarone induced-thyrotoxicosis (AIT) continues to be very challenging for physicians to diagnose and treat properly. The various subtypes can be difficult to identify or result in an easy mix-up. In cases of a poor initial assessment, the best treatment approach can be affected. Amiodarone remains superior to dronedarone as an antiarrhythmic drug especially as it relates to potency, tolerability, and availability. The side effect of amiodarone on thyroid function would not deter physicians from its uses in arrhythmias but rather physicians are encouraged to perform a thorough initial thyroid review of patients and develop a proper follow-up plan for monitoring thyroid function

Conclusion: While the decision to discontinue amiodarone after the onset of thyroid problems is challenging, careful thought should be given to its benefits in stabilizing patients with arrhythmias and the possibility of still having to worsen or prolong thyroid dysfunction symptoms even after stopping the drug due to its prolonged half-life. In order to have a clear distinction between type one and type two AIT, a thorough clinical history needs to be taken, complimented with a physical examination and screening for pre-existing thyroid problems.