P-54 Diabetes mellitus and gynecological cancers in a tertiary hospital in Guyana: exploring correlations, risk factors, and outcomes

Methods: A cross-sectional observational study of 602 women with gynecological cancers (2020–2024) used pathology and oncology records. Descriptive statistics summarized patient characteristics and common types, and multivariable logistic regression identified factors associatyed with DM and cancer progression.

Results: The mean age was 54.5 ± 12.6 years (range: 13–87) and was higher among patients with DM (57.7 ± 11.2) than those without DM (53.6 ± 12.8; p=0.0005). The period prevalence of DM was 23.75% (95% CI: 20.35–27.15%). Afro-Guyanese women constituted the largest proportion of the cohort (37%, n=221); however, the prevalence of DM was highest among Indo-Guyanese women (28.34%, 95% CI: 21.88–34.80%). Cervical cancer was the most common malignancy (47.0%), while vulvar cancer showed the highest proportion of coexisting DM (44.44%) although based on a small sample. Factors associated with DM included family history of diabetes (AOR 3.65) and hypertension (AOR 2.62). Increasing age (AOR 1.03; 95% CI: 1.01–1.06; p=0.009), abnormal uterine bleeding (AOR 3.33; 95% CI: 1.21–9.22; p=0.020) and post-menopausal bleeding (AOR 1.83; 95% CI: 1.02–3.28; p=0.041) were also significantly associated with DM. Approximately fifty-three per cent (53.09%) of diabetic patients; had uncontrolled glycemia. Metformin use was associated with lower odds of cancer progression (AOR 0.27; p=0.009), while hypertension was associated with increased odds (AOR 4.23; p=0.029)

Conclusion: Nearly one in four gynecological cancer patients at GPHC had diabetes, with many showing poor glycemic control. Metformin use was associated with reduced cancer progression, while hypertension was associated with worse outcomes.These findings highlight the need for integrated onco-metabolic care in Guyana.