P-56 The Clinicopathological Profile of Kidney Cancers in Guyana

Methods: This retrospective, cross-sectional study reviewed the medical records of patients who underwent radical nephrectomies for confirmed RCC at the GPHC over five years, nine months period. Data was collected and analyzed using Microsoft Excel and SPSS.

Results: Twenty-six radical nephrectomies were performed for renal masses during the study period. Of these, 18 cases were confirmed as RCC. The average age at diagnosis was 60 years (SD 12.5, range 27-73), with the highest proportion being in East Indian (39%) and mixed (28%) populations. The female-to-male ratio was 1:5.6, with females representing 61% of cases. The majority of cases were found in regions 4 and 2. Flank pain was the primary presenting complaint in 39% of cases, and 33% of tumors were discovered incidentally. No patient had a family history of cancer. Hypertension was the most common comorbidity (61%), followed by Diabetes Mellitus (22%). Tumors were evenly distributed between the right and left kidneys, with no bilateral cases. Tumor locations were defined in 15 cases, with 33% in the upper pole and 27% in the lower pole or renal pelvis. The most common histologic subtype was Clear Cell RCC (61%), followed by Papillary RCC (22%). Among 11 assessable cases, 46% were WHO/IUSP Grade I, and 31% were Grade II. All cases had negative surgical margins, and no lymphovascular invasion was noted.

Conclusion: The average age at diagnosis was 60 years, with a female predominance. The highest highest proportion was of East Indian ethnicity, and hypertension was the most common comorbidity. Flank pain was the major presenting complaint, and Clear Cell RCC was the predominant histologic subtype. Tumors were equally distributed between the right and left kidneys.