Objective: Containing more than 7,000 chemicals, cigarette smoke is attributable to 8 million preventable deaths globally each year. Despite the availability of smoking cessation medication, in 2018, only 7.5% out of 55% of adult smokers who attempted to quit, succeeded. The reasons behind a low successful quit rate are dependent on many factors, including sex differences. Women have been reported to have a more difficult time quitting and achieving abstinence. Women tend to smoke to regulate mood, whereas men are shown to be more sensitive to the effects of nicotine, facilitating physical dependence. Given that yoga has already been shown to have some success in smoking cessation, we discuss the feasibility of developing a yoga-based intervention using sex differences as a guide.