Objective: Since 2010, there has been an unexplained increasing invasion of Sargassum on the coast of Caribbean countries, including Martinique, Guadeloupe, Saint Martin, Saint Kitts, Haiti, Dominican Republic, Cuba, Jamaica, Saint Lucia, Barbados, and Puerto Rico. The objective of this study was to evaluate the clinical characteristics and consequences of long-term exposure to Sargassum gaseous emissions among the local population.